Decoding Health

DAGs, Fatty Liver, and Insulin Resistance: The Metabolic Domino Effect with Michal Ofer

Dr. Urban A. Kiernan Season 1 Episode 194

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Metabolic health is more than blood sugar. In this episode of Decoding Health, Dr. Urban A. Kiernan and returning guest Michal Ofer unpack how fat metabolism—especially ectopic fat stored in the liver, pancreas, and muscle—drives insulin resistance and chronic disease. They explore the personal fat threshold concept, the role of diacylglycerols (DAGs) in blunting insulin signaling, and why focusing on calories or carbs alone misses the bigger picture. The discussion also covers GLP-1 receptor agonists, food additives, seed oils, glyphosate, wheat desiccation, and coatings like Appeal—and how these everyday exposures may disrupt cellular energy and metabolic signaling.

What You'll Learn:

  • Why metabolic health demands attention to fat metabolism, not just glucose control
  • How a personal fat threshold explains diabetes risk at lower body sizes
  • What ectopic fat is and how DAGs impair insulin signaling in liver and pancreas
  • Why both calories and hormones matter—and where very low-carb diets can still stall
  • Concerns raised about GLP-1 receptor agonists, hyperplasia, and post-drug rebound
  • How additives (mono-/diglycerides), seed oils, glyphosate, and produce coatings may act as metabolic disruptors
  • Practical lifestyle levers: muscle-building, movement, sleep, and meal timing

If you’re ready to look beyond tribal diet wars and take a smarter path to metabolic healing, this conversation is for you. #MetabolicHealth #InsulinResistance #EctopicFat #GLP1 #DecodingHealth

Michal Ofer is a highly sought-after nutrition and lifestyle consultant, specializing in a functional medicine approach that prioritizes healing through nutrition and optimizing overall well-being. Michal designs tailored, practical nutrition plans that not only meet your unique health goals but also focus on nutrient density and the critical role of protein in supporting metabolic function, muscle maintenance, hormone balance, and immune health. Her expertise lies in identifying and addressing the barriers and roadblocks that hinder clients from achieving peak health potential, offering strategic and individualized solutions for overcoming these challenges.

Michal has a degree in Life Sciences and is certified as a Master Life Coach. She has received extensive training and accreditation from multiple respected nutrition institutions including The Institute of Functional Medicien, The University of Standford, The University of Colarado and The Institute of Integrative Nutrition. She is dedicated to ongoing education by attending, presenting, and participating in conferences, workshops, and seminars worldwide.

Michal regularly publishes content on multiple platforms, sharing her expertise in personalized nutrition strategies, functional wellness, and protein-centric meal plans. She is also actively involved in private and corporate recipe development, supporting individuals and businesses in actualizing their long-term well-being.

http://michalofer.com 

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Thank you to our sponsor - iMetabolic Biopharma Corporation: Together, we can be the next stage in developing a revolutionary approach to drug discovery.  We give communities the opportunity to invest in their own health as we improve how drugs are discovered to make them more effective and affordable. Visit https://imbiopharma.com/ to learn more.

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