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Decoding Health
Step into the world of Decoding Health, where Dr. Urban A. Kiernan and renowned experts delve into a myriad of fields, unraveling the complexities of science and its practical applications in our daily health. This show is committed to illuminating topics ranging from personal health and wellness to cutting-edge biopharmaceutical advancements and beyond.
Join us each week for an enlightening journey through the realms of science and discover the incredible tools that can enhance your everyday life.
Dr. Urban A. Kiernan holds a Ph.D. Bio-Analytical Chemistry from Arizona State University. His use of the title “doctor” or “Dr.” is in relation to himself and solely refers to that degree as an expert who has significantly contributed to his specific field of science. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. He does not hold any license or credentials for clinical/patient care and any information provided does not create a doctor-patient relationship between Dr. Urban A. Kiernan and you. You should not make any change in your health regimen or diet before first consulting a physician, or equivalent licensed medical provider, and obtain a medical exam, diagnosis, and other recommendations. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition and establishment of treatment plan.
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Decoding Health
Why Natural GLP-1 Disappears So Fast: DPP-4, Half-Life, and How Ozempic-Style Drugs Are Engineered
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GLP-1 is a gut-derived hormone designed to signal the pancreas to produce insulin—but in its natural form, it’s notoriously short-lived. In this Decoding Health segment, we break down why endogenous GLP-1 has an ultra-short half-life (about three minutes), and how the enzyme DPP-4 rapidly “clips” incretin hormones by targeting specific amino acids near the N-terminus—effectively destroying the signal before it can last.
You’ll learn how GLP-1 receptor agonist drugs were engineered to resist DPP-4 degradation, why DPP-4 inhibitor medications (the “gliptins”) extend incretin activity from a different angle, and why measuring GLP-1 in blood samples is scientifically challenging due to ongoing enzyme activity even after blood is drawn. This episode clarifies the biology behind incretins, insulin signaling, and why drug design focuses on stability—while separating the molecule’s function from the controversy around how these therapies are used today.
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Thank you to our sponsor - iMetabolic Biopharma Corporation: Together, we can be the next stage in developing a revolutionary approach to drug discovery. We give communities the opportunity to invest in their own health as we improve how drugs are discovered to make them more effective and affordable. Visit https://imbiopharma.com/ to learn more.
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